Prepare biscuits according to package directions. Set aside.
Place the ground beef and italian sausage into a mixing bowl, and season with onion powder, garlic powder, Italian seasoning, red pepper flakes, black pepper and Worcestershire sauce; mix well. Add 2 eggs, parmesan cheese, and seasoned bread crumbs. Mix until evenly blended. Then form into 1-1/2 inch meatballs, and place onto a baking sheet.
Bake in the preheated oven at 400 degrees until no longer pink in the center, 20 to 25 minutes.
Place one meatball on top of the bottom half of one biscuit. Spoon about one or two teaspoons of marinara sauce on top of each meatball. Sprinkle with a little shredded mozzarella cheese. Return the meatballs with the bottom half of the biscuits to the oven for about 5 minutes to melt the cheese. Top with the other half of the biscuit and serve.