In a large bowl, combine ground beef, chopped onion, onion soup mix, minced garlic, eggs, Italian Seasoned bread crumbs, ketchup, Worcestershire, and if you like, hot sauce. Mix to combine the ingredients but don't overwork it.
To make the sauce, in a small bowl, stir together ketchup, brown sugar, Worcestershire, mustard and hot sauce! If you don't want it hot, you can leave out the hot sauce.
Mold the meatloaf mixture into a loaf and put into a loaf pan or baking dish. Brush the sauce on top of the meatloaf.