Preheat the oven to 350 degrees F. Spray a 9x13 baking dish with cooking spray.
Prepare pasta according to package direction, drain, set aside.
While the pasta cooks, in a large skillet, over medium heat, cook onion for about 5 minutes. Add minced garlic and stir for about one minute. Be careful not to let the garlic burn. Add ground beef and cook until it is browned and no longer pink. Add marinara sauce, Italian seasoning, crushed red pepper, and diced tomatoes and simmer 20 minutes. Add in cubes of softened cream cheese. Stir until melted.
Add the pasta into a baking dish.
Spoon meat mixture over the pasta in the baking dish. Top with mozzarella and parmesan cheese. Cover with aluminum foil.
Bake covered for 25 minutes in the preheated oven. Uncover and bake for another 5 to 10 minutes or until cheese is melted.
Adapted from Baked Ziti I from AllRecipes.com.Nutrition label disclaimer:Nutrient values are estimates only. Variations may occur due to product availability and food preparation. To obtain the most accurate representation of the nutritional information in a given recipe, you should calculate the nutritional information with the actual ingredients used in your recipe, using your preferred nutrition calculator. You are solely responsible for ensuring that any nutritional information provided is accurate, complete, and useful.