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Southern Squash Casserole

Southern Squash Casserole is a comforting side dish casserole, often served during the holidays, with tender, cooked yellow squash, onions,  sour cream and cheddar cheese topped with crushed buttery crackers.
Course Appetizers
Cuisine Southern
Keyword Southern Squash Casserole, squash casserole
Prep Time 20 minutes
Cook Time 40 minutes
Total Time 1 hour
Servings 8
Calories 227kcal
Author Michele @ Flavor Mosaic


  • 2 tablespoons butter
  • 5 yellow squash sliced into 1/4" slices
  • 1 medium onion chopped
  • Salt and pepper to taste
  • ¼ teaspoon cayenne pepper optional
  • 2 eggs
  • 1/2 cup shredded cheddar cheese
  • 1/2 cup Pepper Jack cheese
  • 8 ounces sour cream
  • 2 tablespoons butter
  • 1 sleeve buttery crackers like Ritz crackers
  • 2 Tablespoons melted butter


  • Preheat oven to 350º F.
  • In a large skillet, melt 2 tablespoons butter over medium heat. Add the sliced yellow squash, onions and salt, pepper and cayenne (optional) and cook until tender.
  • In a large bowl, whisk together eggs, cheese, and sour cream. Add cooked squash and onions to egg mixture and stir well to combine.
  • Spray a 9x13 casserole dish with cooking spray and pour squash casserole mixture into the baking dish. Spread the crushed crackers evenly over the top and drizzle melted butter over the crackers. Bake in a preheated oven for about 30 to 40 minutes, or until top has lightly browned.



Calories: 227kcal | Carbohydrates: 6g | Protein: 7g | Fat: 19g | Saturated Fat: 11g | Cholesterol: 91mg | Sodium: 201mg | Potassium: 408mg | Fiber: 1g | Sugar: 4g | Vitamin A: 895IU | Vitamin C: 22.1mg | Calcium: 163mg | Iron: 0.8mg